From the west (Buffalo/Syracuse):
Take Exit 30 off the New York State Thruway (I-90) at Herkimer and take Route 28 South to Cooperstown. After entering the village, turn left onto Chestnut Street. Follow Chestnut Street through the stoplight to Lake Street. Turn left onto Lake Street. The Hotel is located on the right overlooking Lake Otsego.

From the east (Albany):
Take the New York State Thruway (I-90) to Exit 25A and I-88 to Duanesburg (5 miles), Exit 24 then Route 20 West to Route 80 South to Cooperstown. After entering the village, The Otesaga is on the left, just past The Golf Course on Lake Street.

From the south (Binghamton/Oneonta):
Take I-88 to Oneonta, Exit 17 to Route 28 North to Cooperstown. After entering the village follow Chestnut Street through the stoplight to Lake Street. Turn left onto Lake Street. The Hotel is located on the right overlooking Lake Otsego.

From the south (NYC):
Take the New York State Thruway (I-87) north. At Albany, continue on New York State Thruway (I-90 West) to Exit 25A (I-88 Binghamton) to Exit 24 (Duanesburg). Follow Route 20 West to Route 80 South to Cooperstown. After entering the village, The Otesaga is on the left, just past The Golf Course on Lake Street.